At the Centre for Liver Research and Diagnostics, our immunology research is driven by a deep scientific curiosity and a commitment to advancing understanding of the human immune system, particularly its role in infectious diseases, autoimmune disorders, and liver-related pathologies.
Our investigations into infectious diseases focus on the immune response to pathogens such as Entamoeba histolytica, hepatitis B and C viruses, and HIV. Through detailed studies on antibodies, antigens, and cytokines, we have explored how the immune system identifies and combats these infections. Notably, our work on serological detection of hepatitis B surface antigens (HBsAg) and immune complex formation in peptic ulcer disease has provided valuable insights into diagnostic and prognostic markers.
In the domain of liver immunopathology, we have extensively studied the role of immune cells and mediators in conditions like autoimmune hepatitis and chronic liver inflammation. Our research highlights the delicate balance between immune activation and tolerance, and how its disruption can lead to tissue damage and chronic disease progression.
We have also contributed to the understanding of autoimmunity and hypersensitivity, investigating mechanisms such as autoantibody production, leukocyte migration inhibition, and immune suppression. These studies are particularly relevant to diseases like rheumatoid arthritis, ulcerative colitis, and Crohn’s disease, where immune dysregulation plays a central role.
To further dissect immune mechanisms, we employ experimental models, including adoptive transfer studies in animals, to explore cell-mediated immunity and its implications for vaccine development, especially in the context of Entamoeba histolytica.
Our integration of molecular immunology has enabled us to examine gene expression profiles of key immune-related genes, such as mannan-binding lectin (MBL) and various interleukins, to understand their influence on disease susceptibility and progression. This molecular approach not only deepens our understanding of immune complexity but also opens pathways for targeted immunotherapies.
Overall, our immunology research reflects a comprehensive and translational approach from fundamental mechanisms to clinical applications. We are proud to contribute to the evolving landscape of precision medicine and immune-based diagnostics and therapies, reinforcing the central role of the immune system in health and disease.
