At the Centre for Liver Research and Diagnostics, our research under the theme of Genetics and Molecular Biology forms a foundational pillar in unraveling the complexities of health and disease. With over 50 peer-reviewed publications, our work reflects a sustained and in-depth exploration of the molecular mechanisms driving liver disorders, immune dysfunctions, and gastrointestinal diseases.
Our investigations have centered on gene expression profiling and genetic polymorphisms, with a particular focus on genes involved in immune regulation, DNA repair, and metabolic control. Through rigorous studies, we have identified critical associations between polymorphisms in genes such as XRCC1, APE1, and MBL2 and diseases including ulcerative colitis, Crohn’s disease, and COPD. These findings contribute to the growing field of personalized medicine, enabling better risk assessment and tailored therapeutic strategies.
We have also made significant strides in understanding the role of microRNAs (miRNAs) and other non-coding RNAs in disease modulation. Our research has demonstrated their regulatory impact on inflammation, cancer progression, and autoimmune conditions. Importantly, we have explored their potential as non-invasive biomarkers for early detection and monitoring of diseases such as prostate cancer, sepsis, and cardiovascular disorders.
Another key area of our work involves dissecting the molecular basis of immune responses. By analyzing cytokine profiles, chemokine expression, and immune cell markers, we have contributed to a deeper understanding of immune dysregulation in conditions like rheumatoid arthritis, ankylosing spondylitis, and viral infections. These insights are paving the way for targeted immunotherapies.
Our research also emphasizes the interplay between genetic predisposition and environmental triggers, such as infections and toxins. For example, our studies on Helicobacter pylori have shed light on host-pathogen interactions and their role in gastric disease development.
Leveraging bioinformatics and systems biology, we have conducted large-scale gene expression analyses and meta-studies that have revealed novel molecular pathways and signatures. These discoveries are instrumental in developing next-generation diagnostic tools and therapeutic targets.
In summary, our Genetics and Molecular Biology research is distinguished by its scientific depth, translational relevance, and clinical impact. We remain committed to bridging basic science with clinical application, offering molecular insights that address some of the most pressing health challenges of our time.
