At the Centre for Liver Research and Diagnostics, our diagnostics research is a cornerstone of our scientific mission driven by innovation, clinical relevance, and a commitment to improving patient outcomes. Our work focuses on developing and refining diagnostic tools and techniques that enable early detection, precise disease classification, and effective monitoring across a spectrum of health conditions.
We have contributed over 60 peer-reviewed publications in this domain, reflecting our deep engagement with key areas such as biomarkers, serodiagnosis, screening, imaging, and molecular diagnostics. Our research spans both traditional biochemical assays and cutting-edge molecular technologies, including PCR-based genotyping, ELISA, and colorimetric biosensors.
Focus Areas and Impact
Our diagnostics research has made significant strides in addressing infectious diseases such as amoebiasis, hepatitis B and C, and Helicobacter pylori infections. Through the development of serological tests, immune complex detection, and antigen-based assays, we have enabled more accurate and timely diagnosis especially critical in endemic and resource-limited regions.
We have also advanced the understanding of gastrointestinal and liver diseases by identifying and validating biomarkers like serum pepsinogen, histaminase, and alpha-1-antitrypsin, which aid in assessing disease severity and progression. These insights are vital for preventive healthcare and early intervention strategies.
In recent years, our research has expanded into molecular and genetic diagnostics, exploring gene expression profiles, microRNA biomarkers, and genotyping techniques for complex conditions such as cancer, ulcerative colitis, and sepsis. These studies pave the way for personalized medicine, where treatment decisions are informed by individual molecular signatures.
Representative Contributions
Some of our notable studies include:
- Filter paper technique for serodiagnosis of amoebiasis
- ELISA and RPHA-based immunodiagnostics for hepatitis B surface antigen detection
- Colorimetric assay for serum lysyl oxidase estimation
- Multiplex PCR assay for virulent Helicobacter pylori detection
- Antisense oligonucleotide-mediated colorimetric sensing of viral RNA without PCR amplification
- Transmission pathway analysis of Helicobacter pylori at oral and gastroduodenal sites
- Circulating miRNA expression profiling linked to cardiovascular pathogenesis in women
- MicroRNA-21 as a non-invasive biomarker for prostate cancer
- Cell-free mitochondrial DNA quantification for real-time monitoring in ischemic stroke
- Detection of circulating immune complexes in peptic ulcer patients
Our Vision
Through our diagnostics research, we aim to bridge the gap between laboratory innovation and clinical application. By developing both lab-based and field-deployable diagnostic tools, we contribute to early intervention, disease surveillance, and treatment optimization especially in settings where access to advanced healthcare is limited.
