Check Our Research Studies on
Stem Cells and Regenerative Medicine
The Centre for Liver Research & Diagnostics presents a curated collection of 63 research publications in Stem Cells and Regenerative Medicine, spanning from 1990 to 2021. These studies reflect our commitment to advancing regenerative medicine through innovative approaches in tissue engineering, stem cell therapy, and molecular diagnostics. The research encompasses hepatic and pancreatic regeneration, neural and spinal applications, mesenchymal and dental stem cell therapies, and translational molecular insights. Each paper contributes to the future of personalized and transplant-free therapies, offering transformative benefits in clinical care and biomedical innovation.
Neurology India, 2021
A comprehensive stemness gene expression analysis signifies the role of ABC transporters and molecular chaperons in determining the fate of human neural precursor cells.Authors: Vishwakarma SK, Bardia A, Reddy C, Paspala SAB, Khan AA
Therapie. 2021 May-Jun;76(3):201-210
Efficacy and safety of neural stem cell therapy for spinal cord injury: A systematic literature review.Authors: Tiwari S, Khan S, Kumar SV, Rajak R, Sultana A, Pasha SA, Gauba D, Ghosh P, Khurana T, Kulkarni A, Reddy YP, Khan AA, Sharma VK
J Contemp Dent Pract. 2019 Oct 1;20(10):1171-1178
Osteo/odontogenic Differentiation of Human Mesenchymal Stem Cells with Platelet-rich Plasma and Mineral Trioxide Aggregate.Authors: Vanka A, Vishwakarma SK, Bhat MK, Vanka S, Wali O, Khan AA
Asian Journal of Pharmaceutical Research and Health Care, 2019; 11:1
Gene Expression during Osteo/Odontogenic Differentiation of Mesenchymal Stem Cells with Platelet Rich Plasma and Mineral Trioxide Aggregate.Authors: Amit Anandswarup Vanka, Shanthi Vanka, Sandeep Vishwakarma, Manohar Bhat, Dinesh Rao, Othman Wali, Aleem Khan
Tissue and Cell, 2018; 51:14-23
Role of drug transporters and heat shock proteins during ethanol exposure to human neural precursor cells and its lineages.Authors: Vishwakarma SK, Fathima N, Lakkireddy C, Raju N, Bardia A, Sandhya A, Paspala SAB, Vishnupriya S, Khan AA
Tissue and Cell, 2017; 49(6):638-647
Enhanced neuroprotective effect of mild-hypothermia with VPA against ethanol–mediated neuronal injury.Authors: Vishwakarma SK, Bardia A, Chandrakala L, Arshiya S, Paspala SAB, Sandhya A, Vishnupriya S, Khan AA
Basic and Clinical Neuroscience, 2017; 8(6):453-466
Protective role of hypothermia against heat stress in differentiated and undifferentiated human neural precursor cells: An in vitro model to study the attenuated heat shock response.Authors: Vishwakarma SK, Bardia A, Fathima N, Rahamathulla S, Raju N, Srinivas G, Raj A, Sandhya A, Vishnupriya S, Tiwari SK, Paspala SAB, Khan AA
Liver Pathophysiology: Therapies and Antioxidants, Elsevier, Chapter 59, 2017
Repopulation of Cirrhotic Liver by Hepatic Stem/Progenitor Cells: A Promising Strategy Alternative to Liver Transplantation.Authors: Khan AA, Vishwakarma SK, Bardia A, Habeeb MA, Dayal M
Alcoholism: Clinical and Experimental Research, 2017; 41(6):1078-1092
Protective Effects of Diallyl Sulfide Against Ethanol-Induced Injury in Rat Adipose Tissue and Primary Human Adipocytes.Authors: Kema VH, Khan I, Jamal R, Vishwakarma SK, Lakkireddy C, Parwani K, Patel F, Patel D, Khan AA, Mandal P
Indian Journal of Science and Technology, 2017; 10(29):1-12
Regeneration of Neural Crest Cells from Human Postnatal Multipotent Dental Pulp Stem Cells.Authors: Fathima N, Vishwakarma SK, Khan AA
Journal of Transplantation Technologies & Research, 2015, 5:2
Transplantation of Epcam+Ve Human Hepatic Stem Cells in Liver Cirrhosis Patient and Cellular Immune Response Running Title: Transplantation and Cellular Immune Response.Authors: Aleem Ahmed Khan, Sivaram G, Sandeep Kumar Vishwakarma, Chandrakala Lakki Reddy, Srinivas G, Avinash Raj, Pratibha Nallari, Md Aejaz Habeeb and Venkateswarlu J
J Dia Res Ther, 2015; 1:1
Trans-differentiated Human Hepatic Progenitors into Insulin Producing Β-Cells: a Step Closer Towards the Diabetes Cell Therapy.Authors: Vishwakarma KS, Bardia A, Nallari P, Habeeb A, Khan AA
ADMET and DMPK, 2015
Metabolism of Six CYP Probe Substrates in Fetal Hepatocytes.Authors: Abdul Naveed Shaik, Sandeep Kumar Vishwakarma, Aleem Ahmed Khan
World Journal of Stem Cells, 2015; 7(5):859-65
Hepatic stem cells: A viable approach for the treatment of liver cirrhosis.Authors: Habeeb MA, Vishwakarma SK, Bardia A, Khan AA
Journal of Advanced Research, 2014; 5(3):277-294
Current Concept in Neural Regeneration Research: NSCs Isolation, Characterization and Transplantation in Various Neurodegenerative Diseases and Stroke.Authors: Vishwakarma SK, Bardia A, Sivaram G, Tiwari SK, Paspala SAB, Khan AA
Journal of Diabetes Investigation, 2014; 5(5):492–500
In vitro quantitative and relative gene expression analysis of pancreatic transcription factors Pdx-1, Ngn-3, Isl-1, Pax-4, Pax-6 and Nkx-6.1 in trans-differentiated human hepatic progenitors.Authors: Vishwakarma SK,Rahamathulla S, Bardia A, Tiwari SK, Srinivas G, Raj A, Tripura C, Sandhya A, Habeeb MA, Khan AA, Pande G. Reddy KP, Reddy PY
Cell Biology: Research and Therapy, 2014; 3:1
Pande G. Isolation and characterization of stem cells sub population within the human fetal liver.Authors: Vali SM, Vishwakarma SK,Bardia A, Tiwari SK, Srinivas G, Raj A, Tripura C, Habeeb MA, Khan AA
International Journal of Advanced Research, 2014; Volume 2, Issue 2, 561-567
In vitro proliferation of MSCs using mineral trioxide aggregate: A most recent material for in situ stem cells mobilization.Authors: Vanka Amit, Sandeep K Vishwakarma, G Shanthi, Manohar K Bhat, Aleem Ahmed Khan
Journal of Cell and Molecular Research, 2014
ATP-binding cassette (ABC) transporters as emerging targets in modulation of neural stem cells behavior in neurodegenerative diseases and cell therapy benefits.Authors: Sandeep Kumar Vishwakarma, Syed Ameer Basha Paspala, Santosh K Tiwari, Aleem A Khan
International Journal of Bioinformatics and Biological Science, May, 2014
Mining of Expressed Sequence Tags for Identification of ATP Binding Cassette Transporters in Human Brain.Authors: Sandeep Kumar Vishwakarma, Syed Ameer Basha Paspala, Aleem Ahmed Khan
International Journal of Advancements in Research and Technology, 2013
Stem cells: Frontier in disease research and development.Authors: Sandeep K Vishwakarma, Syed Ameer Basa Paspala, Avinash Bardia, Santosh K Tiwari, Aleem Ahmed Khan
International Journal of Advanced Research (2013), Volume 1, Issue 9, 782-793
Isolation and characterization of neural precursor cells from different regions of human fetal brain: Assessment of in vitro proliferation and differentiation.Authors: Sandeep Kumar Vishwakarma, Syed Ameer Basha Paspala, Avinash Bardia, Santosh K Tiwari, G. Srinivas, Avinash Raj, Aleem Ahmed Khan
International Journal of Advanced Research (2013), Volume 1, Issue 10, 157-164
In vitro assessment of osteogenic and chondrogenic differentiation potential of human bone marrow derived mesenchymal stem cells.Authors: Sandeep Kumar Vishwakarma, Mazaharuddin A Khan, Avinash Bardia, Santosh K Tiwari, Aleem Ahmed Khan
Stem Cells and Cloning: Advances and Applications, 2012; 5:1–13
Potential role of stem cells in severe spinal cord injury: Current perspectives and clinical data.Authors: Paspala SAB, Vishwakarma SK, Murthy TVRK, Rao TN, Khan AA
Curr Pharm Biotechno. 2011; 12(2):226-230
An update on hepatic stem cell: bench to bedside.Authors: Parveen N, Aleem AK, Habeeb MA, Habibullah CM
Cell Transplant 2010;19(4):409-18
Human fetal liver derived stem cell transplantation as supportive modality in the management of end stage decompensated liver cirrhosis..Authors: Aleem AK, Mahaboob VS, Parveen N, Rajendraprasad A, Mohammed AA, Aejaz HM, Srinivas G, Avinash RT, Santosh KT, Kumaresan K, Venkateswarlu J, Gopal P, CM Habibullah
Diabetes Technology and Therapeutics 2010 Vol. 12, No. 5
In vitro Insulin production and analysis of pancreatic transcription factors in induced human hepatic progenitor cells.Authors: Aleem AK, Rajendraprasad A, Parveen N, Mahaboob VS,Santosh KT, Srinivas G, Avinash RT, Aejaz HM, G Pande, CM Habibullah
Journal of Proteomics & Bioinformatics 2009; 2: 398-407
Proteomic analysis of the “Side Population” (SP) cells from murine bone marrow.Authors: Ravipati S, Azra F, Sundaram CS, Anabalagan C, Saritha CV, Srinivas G, Khan AA, CM Habibullah, Gopal P
Indian Journal of Medical Research 2009; 130: 379-91
Neural stem cells & supporting cells - The new therapeutic tools for the treatment of spinal cord injury..Authors: Syed Ameer Basha Paspala, Balaji AB, Parveen N, Ahmed KS, Khan AA, Mohammed Nane Khaja, Lakshmi Narsu M, Prameela Devi Y, Murthy TVRK, CM Habibullah
World Journal of Gastroenterology 2008; 14(37): 5730-37
Characterization of hepatic progenitors from human fetal liver during second trimester.Authors: Mekala SR, Aleem AK, Nyamath P, Mohammed AH, CM Habibullah, Gopal P
Hepatitis monthly 2008; 8(4): 275-280
Intraperitoneal transplantation of hepatocytes embedded in Thermoreversible Gelation Polymer (Mebiol Gel) in acute liver failure rat model.Authors: Parveen N, Aleem AK, Baskar S, Habeeb MA, Ravinder B, Samuel A, Hiroshi Y, Yuichi M,CM Habibullah
Transplantation proceedings 2008; 40(4): 1140-44
Safety and Efficacy of Autologous Bone Marrow Stem Cell Transplantation through Hepatic Artery for the Treatment of Chronic Liver Failure: A Preliminary Study..Authors: Khan AA, Parveen N, Mahaboob VS, Rajendra P, Ravundra P, Venkateswarlu, Rao SGA, Narusu ML, Khaja MN, Pramila A, Habeeb MA, CM Habibullah
Transplantation proceedings 2008; 40(4):1148-50
Treatment of Crigler-Najjar Syndrome type-I by hepatic progenitor cell transplantation: A simple procedure for management of hyperbilirubinemia.Authors: Khan AA, Parveen N, Mahboob VS, Rajendra P, Ravindraprakash B, Venkateswarlu J, Rao P, Habeeb MA, CM Habibullah
Transplantation proceedings 2008; 1(40):1153-55
Management of hyperbilirubenemia in biliary atresia by hepatic progenitor cell transplantation through hepatic artery.Authors: Khan AA, Parveen N, Mahaboob VS, Rajendra Prasad A, Ravindraprakash, Venkateswarlu J, Rao SGA, Pande G, Narusu ML, Khaja MN, Pramila A, Habeeb MA, CM Habibullah
Indian Journal of Gastroenterology 2007; 26(1): S23-25
Stem cells in digestive diseases.Authors: CM Habibullah
World Journal of Gastroenterology 2007; 13(16): 2319-23
Characterization of hepatic progenitors from human fetal liver using CD34 as a hepatic progenitor marker.Authors: Parveen N, Ayesha A, Habeeb MA, Khosla S, Khan AA, CM Habibullah
Transplantation Proceedings 2007; 39: 694–99
Stem cell therapy—present status.Authors: Aejaz HM, Aleem AK, Parveen N, Khaja MN, Narusu ML, CM Habibullah
Proceedings of Andhra Pradesh Academy of Sciences 2006; 10(1): 17-21
Liver stem cell therapy-current concepts.Authors: Parveen N, Aleem AK, Aejaz HM, CM Habibullah
Indian Journal of Medical Research 2006; 123(5): 601-14
Journey from hepatocyte transplantation to hepatic stem cells: A novel treatment strategy for liver diseases.Authors: Aleem AK,Parveen N, Habeeb MA and CM Habibullah
Journal of Stem Cells and Regenerative Medicine 2006; 1(1) (DOI:001010200002)
Stem cells in hepatobiliary diseases.Authors: Aejaz HM, Khan AA, Parveen N, Baskar S, Mahaboob V, Khaja MN, Lakshmi NM and CM Habibullah
Indian Journal of Medical & Pediatric Oncology 2005; 26 (Suppl 3): 27-29
Stem cells in the treatment of liver disorders.Authors: CM Habibullah
Molecular and Cellular Biochemistry 2005; 277: 1-2: 49-53
Effect of ultraviolet B (302 nm) irradiation on viability, metabolic and detoxification functions of goat hepatocytes – in vitro study.Authors: Naseem B, Vijayalakshmi V, ParveenN, Capoor AK, Aejaz HM, AA Khan, S Muzeeb, Rao NVS, Mamidi, CM Habibullah
Journal of Gastroenterology and Hepatology.2004;19:1029–35
Comparison of Biochemical and cytotoxic functions of hepatocytes from goat, pig and human fetus.Authors: Vijayalakshmi V, Naseem B, Khan AA, Capoor AK, CM Habibullah
The Indian Veterinary Journal 2003; 80: 1010-14
Screening For Zoonosis In Goat Liver/Blood-Implications in Xenotransplantation.Authors: Naseem B, Vijayalakshmi V, Khan AA, Capoor AK,CM Habibullah
Cell Biochemistry and Function 2004; 22(2): 89-96
Tyrosine aminotransferase and gamma-glutamyl transferase activity in human fetal hepatocyte primary cultures under proliferative conditions.Authors: Rehman KK, Ayesha Q, Khan AA, Niyaz Ahmed, CM Habibullah
Indian Journal of Gastroenterology. 2002; 21(2): 55-58
In vitro studies on a bioreactor module containing encapsulated goat hepatocytes for the development of bioartificial liver.Authors: Aleem AK, Adarsh KC, Parveen N, Shakeel Naseem, Vijayalakshmi VV, CM Habibullah
Acta medica et biologica 1999; 47(3): 97-102
In vitro assessment of microencapsulation in providing immuno- protection against antibody-mediated cell lysis.Authors: Khan AA, Adarsh C, CM Habibullah
Burns 1999; 25(3): 223-225
The effect of an anti-allergic agent avil in abnormal scar fibroblast.Authors: Venugopal J, Ramakrishnan M, CM Habibullah, Mary B
Cell Transplantation1998; 7(3): 267-273
In situ localization of intrasplenic transplanted hepatocytes by using FISH technique.Authors: CM Habibullah
Hepatocyte Transplantation 1997: 312-21
An overview of hepatocyte transplantation - Fulminant hepatic failure.Authors: CM Habibullah
Gene 1997; 190 (1): 217-221
Non-viral ex-vivo hepatic gene transfer by in-situ lipofection of liver and Intraperitoneal transplantation of hepatocytes.Authors: Rangarajan PN, Vatsala PG. Ashok MS, Srinivas VK, CM Habibullah, Padmanabhan
International Hepatology Communication 1995; (4): 183-189
Xenogenic transplantation of microencapsulated hepatocytes ureagenesis of retrieved encapsulated hepatocytes.Authors: Khan AA, CM Habibullah, Ayesha Q, Lahiri S
Transplantation 1995; 59(10): 1495-1497
Xenotransplantation of UV-B irradiated hepatocyte survival and immune response.Authors: CM Habibullah, Ayesha Q, Khan AA, Naithani R, Lahiri S
Liver 1995; 15: 149-152
Effect of UV-B (302nm) irradiation on isolated rat hepatocytes.Authors: Lahiri S, CM Habibullah, Ayesha Q, Khan AA, Srinivas VK, Naithani R
Transplantation1994; 58: 951-52
Human fetal hepatocyte transplantation in patients with fulminant hepatic failure.Authors: CM Habibullah, Syed IH, Qamer A, Taher-uz-Z
Medical Science Research 1993; 21 (24): 909-910
Detoxification of ammonia by human fetal hepatocytes preserved media Supplemented with human placental cord serum.Authors: Mohsin S, CM Habibullah, Srinivas VK, Ayesha Q, Hassan SI
Biochemistry and Cell Biology 1993; 71: 241-247
Ontogeny of hepatocyte proliferation inhibitor activity during human liver development and its effect on cell proliferation in in-vivo and in-vitro studies.Authors: Geetha DB, CM Habibullah, Gupta PD
Medical Science Research 1993; 21: 245-246
Maintenance of proliferative cultures of human fetal hepatocytes using media supplemented with human placental cord serum.Authors: Srinivas VK, CM Habibullah, Ibrahim HS, Qamer Ayesha, Khaleel-ur-Rehman K, Nayeem MA
Medical Science Research 1993; 21: 683-684
Tyrosine amino transferase in isolated hepatocytes from fetuses of different gestation.Authors: Khaleel-ur-Rehman K, CM Habibullah, Qamer Ayesha, Nayeem MA, Hassan SI, Srinivas VK
Biochemistry International 1992; 28(1): 41-49
Changes in membrane fluidity during human liver development.Authors: Geetha DB, Gupta PD, CM Habibullah
Biochemistry International 1992; 28(2): 229-237
Glycogen metabolism during human liver development.Authors: Geetha Devi B, CM Habibullah, Gupta PD
Pediatrics Research 1992; 31:143-145
Studies on urea cycle enzyme levels in the human fetal liver at different gestational ages.Authors: Baig MA, CM Habibullah, Swamy M, Hussain SJ, Zaman TU, Ayesha Q, Devi BG
Surgical Research Communication 1990; (8): 87-90
Fetal liver perfusion – A new approach.Authors: CM Habibullah, Ibrahim S, Ayesha Q, Zaman TU, Baig MA, Geeta B
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Impact of our Research
This body of work demonstrates the Centre’s leadership in stem cell research, integrating stem cell biology, scaffold fabrication, molecular diagnostics, and translational medicine. The studies on liver and pancreatic constructs offer viable alternatives to organ transplantation, while neurological and spinal research supports neuroregenerative therapies. Mesenchymal and dental stem cell studies enhance tissue repair strategies, and molecular insights enable non-invasive diagnostics and personalized interventions. Together, these contributions position the Centre at the forefront of next-generation regenerative medicine and precision healthcare.
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Hepatic and Pancreatic Regeneration
Research in this category focuses on developing humanized liver grafts and insulin-producing neo-organs using stem cells and decellularized scaffolds. These innovations offer promising alternatives to traditional organ transplantation and support regenerative therapies for liver failure and diabetes.
1990 – 2017
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Neural and Spinal Stem Cell Applications
This research emphasizes the use of decellularized meningeal scaffolds and neuroprotective strategies to restore neural function. It supports the development of personalized therapies for stroke, spinal injury, and ethanol-induced neurotoxicity, contributing to the future of bioengineered and neuroregenerative medicine.
2009 – 2021
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Mesenchymal and Dental Stem Cells
Research in this domain focuses on osteo/odontogenic differentiation of mesenchymal stem cells using biomaterials like platelet-rich plasma and mineral trioxide aggregate. These approaches enhance tissue repair and regeneration in dental and orthopedic applications, the differentiation potential of mesenchymal and dental stem cells.
2009 – 2019
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Translational and Molecular Insights
This category includes studies on miRNA signaling, ABC transporters, and molecular chaperones that influence stem cell fate and regenerative potential. The findings contribute to non-invasive diagnostics and personalized treatment strategies, investigate molecular markers and genetic pathways.
1993 – 2017